Phyusion Bio

Advancing innovations at the intersection of biology, technology, and AI.

Explore the intersection
Where we work

Three fields are converging. The life sciences are what changes.

Select a domain to see what it contributes and the published work of founder Sean Khozin, MD, MPH, behind it. The center is where Phyusion Bio operates.

Biology Technology AI Real-world evidence Computable biology Learning systems Convergence

Convergence

Where the three overlap, the unit of evidence changes.

Biology supplies the questions and the ground truth. Technology makes biology continuously measurable at the level of the individual. AI turns those measurements into models that can be interrogated, updated, and acted on.

Together they make the life sciences behave less like a sequence of one-off experiments and more like a learning system: trials that borrow strength from external data without giving up randomization, evidence generated at the point of care and not only in the trial, disease classified by mechanism instead of anatomy, and therapies matched to an individual rather than a population average.

This is where Phyusion Bio works. Not at any single node, but in the operating system that connects them.

Peer-reviewed

  1. Real-world evidence in support of precision medicine: clinico-genomic cancer data as a case studyAgarwala V, Khozin S, Singal G, et al. Health Affairs 2018
  2. Status update on data required to build a learning health systemBertagnolli MM, Anderson B, Norsworthy K, ... Khozin S. Journal of Clinical Oncology 2020
  3. The design and evaluation of hybrid controlled trials that leverage external data and randomizationVentz S, Khozin S, Louv B, et al. Nature Communications 2022
  4. Unleashing the power of clinical trial data: a proposal for enhancing informed consent and data sharingTrippa L, Khozin S. The Oncologist 2024

From the Substack

  1. Everything is a SignalThe future arrives as a collection of weak signals most people overlook
  2. The End of Disciplinary SovereigntyLarge language models abstract across medicine, finance, and science, dissolving the boundaries between disciplines
  3. Ideas That Refuse to DieWith Peter Kolchinsky on the people and systems that decide whether an idea becomes a medicine
  4. You Can’t Win AloneOn collective leadership, and why Precision Signals was built on the premise that progress happens when silos dissolve